Mesehist DM

Generic Name: chlorpheniramine, dextromethorphan, and pseudoephedrine (klor feh NEER a meen, dex tro meh THOR fan, and soo doe eh FEH drin)

Brand Names: AccuHist PDX Drops, Atuss DS, Children's NyQuil, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Dicel DM, Dicel DM Chewables, Entre-S, Esocor P, Kidcare Cough and Cold, M-End DM, Mesehist DM, Neutrahist PDX Drops, Nyquil Child Cough and Cold, Pediatric Cough & Cold Medicine, Rescon-DM, Robitussin Pediatric Night Relief, Robitussin PM Cough & Cold, Triaminic Cold and Cough, Triaminic Multi-Sympton, Triaminic Night Time, Triaminic Softchew Cold and Cough, Triaminic-D Multi-Symptom Cold, Vicks 44M Pediatric, Vicks Pediatric Formula 44M

What is Mesehist DM (chlorpheniramine, dextromethorphan, and pseudoephedrine)?

Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of chlorpheniramine, dextromethorphan, and pseudoephedrine is used to treat runny or stuffy nose, sneezing, itching, watery eyes, cough, and sinus congestion caused by allergies, the common cold, or the flu.

Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema.

Chlorpheniramine, dextromethorphan, and pseudoephedrine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Mesehist DM (chlorpheniramine, dextromethorphan, and pseudoephedrine)?

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not use a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Ask a doctor or pharmacist before taking this medicine if you have heart disease, high blood pressure, kidney disease, diabetes, glaucoma, a thyroid disorder, emphysema or bronchitis, an enlarged prostate, or urination problems.

Do not use cold or cough medicine without your doctor's advice if you are pregnant or breast-feeding. Ask a doctor or pharmacist before using any other cold, cough, or allergy medicine. Chlorpheniramine, dextromethorphan, and pseudoephedrine are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine, cough suppressant, or decongestant. Do not take this medicine for longer than 7 days in a row. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

What should I discuss with my healthcare provider before taking Mesehist DM (chlorpheniramine, dextromethorphan, and pseudoephedrine)?

Do not use a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

• 
  

  heart disease or high blood pressure;

  
  


• 
  

  kidney disease;

  
  


• 
  

  diabetes;

  
  


• 
  

  glaucoma;

  
  


• 
  

  a thyroid disorder;

  
  


• 
  

  emphysema or chronic bronchitis;

  
  


• 
  

  an enlarged prostate; or

  
  


• 
  

  problems with urination.

  
  

FDA pregnancy category C. It is not known whether chlorpheniramine, dextromethorphan, and pseudoephedrine will harm an unborn baby. Do not use this medication without medical advice if you are pregnant. Chlorpheniramine, dextromethorphan, and pseudoephedrine may pass into breast milk and may harm a nursing baby. Do not use cold or cough medicine without medical advice if you are breast-feeding a baby.

Artificially sweetened liquid cough or cold medicine may contain phenylalanine. If you have phenylketonuria (PKU), check the medication label to see if the product contains phenylalanine.

How should I take Mesehist DM (chlorpheniramine, dextromethorphan, and pseudoephedrine)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cough or cold medicine is usually taken only for a short time until your symptoms clear up.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

The chewable tablet should be chewed before you swallow it.

Shake the oral suspension well just before you measure a dose. Do not take this medicine for longer than 7 days in a row. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

This medication can cause unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

If you need surgery, tell the surgeon ahead of time if you have taken a cough or cold medicine within the past few days. Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since cough or cold medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking Mesehist DM (chlorpheniramine, dextromethorphan, and pseudoephedrine)?

This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Chlorpheniramine can decrease sweating and you may be more prone to heat stroke.

Drinking alcohol can increase certain side effects of this medication.

Avoid taking this medication if you also take diet pills, caffeine pills, or other stimulants (such as ADHD medications). Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Ask a doctor or pharmacist before using any other cold, cough, or allergy medicine. Chlorpheniramine, dextromethorphan, and pseudoephedrine are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine, cough suppressant, or decongestant.

Mesehist DM (chlorpheniramine, dextromethorphan, and pseudoephedrine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using this medicine and call your doctor at once if you have a serious side effect such as:

• 
  

  fast, pounding, or uneven heartbeats;

  
  


• 
  

  slow, shallow breathing;

  
  


• 
  

  confusion, hallucinations, unusual thoughts or behavior;

  
  


• 
  

  severe dizziness, anxiety, restless feeling, or nervousness;

  
  


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  urinating less than usual or not at all;

  
  


• 
  

  easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or

  
  


• 
  

  dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

  
  

Less serious side effects may include:

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  dry mouth, nose, or throat;

  
  


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  mild stomach pain, constipation;

  
  


• 
  

  blurred vision;

  
  


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  dizziness, drowsiness, mild headache;

  
  


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  sleep problems (insomnia);

  
  


• 
  

  feeling restless or excited (especially in children);

  
  


• 
  

  problems with memory or concentration; or

  
  


• 
  

  flushing (warmth, redness, or tingly feeling).

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Mesehist DM (chlorpheniramine, dextromethorphan, and pseudoephedrine)?

Before using this medicine, tell your doctor if you regularly use other medicines that make you sleepy (such as sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by chlorpheniramine, dextromethorphan, and pseudoephedrine.

Ask a doctor or pharmacist if it is safe for you to use chlorpheniramine, dextromethorphan, and pseudoephedrine if you are also using any of the following drugs:

• 
  

  glycopyrrolate (Robinul);

  
  


• 
  

  mepenzolate (Cantil);

  
  


• 
  

  atropine (Atreza, Sal-Tropine), belladonna (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm Scop);

  
  


• 
  

  bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);

  
  


• 
  

  bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);

  
  


• 
  

  a diuretic (water pill), or blood pressure medicine;

  
  


• 
  

  irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro Banthine); or

  
  


• 
  

  salicylates such as aspirin, Backache Relief Extra Strength, Novasal, Nuprin Backache Caplet, Doan's Pills Extra Strength, Pepto-Bismol, Tricosal, and others.

  
  

This list is not complete and other drugs may interact with chlorpheniramine, dextromethorphan, and pseudoephedrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Mesehist DM resources

• Mesehist DM Side Effects (in more detail)
• Mesehist DM Use in Pregnancy & Breastfeeding
• Mesehist DM Drug Interactions
• 0 Reviews for Mesehist DM - Add your own review/rating

• AccuHist PDX Drops MedFacts Consumer Leaflet (Wolters Kluwer)


• AccuHist PDX Drops Prescribing Information (FDA)


• Dicel DM Chewables Chewable Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Entre-S Prescribing Information (FDA)

Compare Mesehist DM with other medications

• Cough and Nasal Congestion

Where can I get more information?

• Your pharmacist can provide more information about chlorpheniramine, dextromethorphan, and pseudoephedrine.

See also: Mesehist DM side effects (in more detail)

Meclofenamate

Pronunciation: mek-loe-FEN-uh-mate
Generic Name: Meclofenamate
Brand Name: Generic only. No brands available.

Meclofenamate is a nonsteroidal anti-inflammatory drug (NSAID). NSAIDs have been associated with serious, possibly fatal, heart and blood vessel risks, such as heart attack and stroke. This risk increases with long-term use of NSAIDs or if you have heart problems. NSAIDs should not be used right before or after bypass heart surgery. Additionally, NSAIDs can cause serious, possibly fatal stomach ulcers and bleeding, which can occur without warning signs. The following factors increase the risk of serious stomach problems in patients being treated with NSAIDs: history of stomach bleeding or ulcer disease, long-term use of NSAIDs, smoking, use of alcohol, poor health, older age, or use of certain medicines, such as anticoagulants (eg, warfarin) or corticosteroids (eg, prednisone), while taking an NSAID. To reduce your risk of serious side effects, take Meclofenamate exactly as instructed, at the lowest dose possible, and for the shortest time needed.

Meclofenamate is used for:

Treating rheumatoid arthritis, osteoarthritis, menstrual cramps, and mild to moderate pain. It may also be used for other conditions as determined by your doctor.

Meclofenamate is an NSAID. It works by preventing prostaglandins from being produced by the injured tissue. It may take several days before maximum relief is noticed. NSAIDs relieve symptoms of inflammation but do not alter the course of the underlying disease.

Do NOT use Meclofenamate if:

• you are allergic to any ingredient in Meclofenamate or similar medicines

Contact your doctor or health care provider right away if any of these apply to you.

Before using Meclofenamate:

Some medical conditions may interact with Meclofenamate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to aspirin or an NSAID (eg, ibuprofen, naproxen, celecoxib)


• if you have kidney or liver disease, diabetes, stomach problems (eg, bleeding, perforation, ulcers), heart disease, high blood pressure, swelling, blood disorders, bleeding or clotting problems, asthma, growths in the nose (nasal polyps), canker sores, if you consume alcoholic beverages, or if you are dehydrated

Some MEDICINES MAY INTERACT with Meclofenamate. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin), corticosteroids (eg, prednisone), cyclosporine, heparin, lithium, methotrexate, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because actions and side effects of these medicines may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Meclofenamate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Meclofenamate:

Use Meclofenamate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Meclofenamate comes with an additional patient information sheet called a Medication Guide. Read it carefully and reread it each time you get Meclofenamate refilled.


• Meclofenamate may be taken with food if it upsets your stomach. Taking it with food may not decrease the risk of stomach or bowel problems (such as bleeding or ulcers) that may occur while taking Meclofenamate. Talk with your doctor or pharmacist if you experience persistent stomach upset.


• Take Meclofenamate with a full glass (8 oz/240 mL) of water as directed by your doctor.


• Swallow whole. Do not crush, break, or chew before swallowing.


• Do not lie down for 30 minutes after taking Meclofenamate.


• If you miss a dose of Meclofenamate, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Meclofenamate.

Important safety information:

• Meclofenamate may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Meclofenamate. Using Meclofenamate alone, with other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks. Limit alcoholic beverages.


• Serious stomach ulcers or bleeding can occur with Meclofenamate. Taking Meclofenamate in high doses, taking it for long periods of time, or drinking alcohol increases the risk of these side effects. Taking Meclofenamate with food will NOT reduce the risk of these effects. If you have severe stomach or back pain; black, tar-like stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling, contact your doctor or emergency room immediately.


• Avoid taking aspirin while taking Meclofenamate unless advised to do so by your health care provider.


• Meclofenamate may alter certain lab test results. Make sure lab personnel and your doctors know you use Meclofenamate.


• LAB TESTS, including liver function, kidney function, and complete blood cell counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.


• Caution is advised when using Meclofenamate in the ELDERLY because they may be more sensitive to its effects, especially stomach bleeding and kidney effects.


• Meclofenamate is not recommended for use in CHILDREN younger than 14 years of age. Safety and effectiveness in this age group have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Meclofenamate may cause harm to the fetus. Avoid becoming pregnant while taking Meclofenamate. If you think you may be pregnant, discuss with your doctor the benefits and risks of using Meclofenamate during pregnancy. Meclofenamate is excreted in breast milk. Do not breast-feed while taking Meclofenamate.

Possible side effects of Meclofenamate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; headache; heartburn; indigestion; nausea; stomach upset; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; itching; tightness in the chest; swelling of the mouth, face, lips, or tongue); black stools; change in the amount of urine; dark urine; easy bruising/bleeding; fast heartbeat; fever; mental/mood changes; persistent sore throat; persistent stomach or abdominal pain; pounding in the chest; ringing in the ears; severe headache; stiff neck; stomach pain; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual tiredness; vision changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Meclofenamate side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; coffee ground-like vomit; difficult or slowed breathing; disorientation; dizziness; extreme drowsiness; extreme tiredness; loss of consciousness; mental confusion; numbness; ringing in the ears; seizures; severe stomach pain; unusually fast or slow heartbeat.

Proper storage of Meclofenamate:

Store Meclofenamate at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Meclofenamate out of the reach of children and away from pets.

General information:

• If you have any questions about Meclofenamate, please talk with your doctor, pharmacist, or other health care provider.


• Meclofenamate is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Meclofenamate. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Meclofenamate resources

• Meclofenamate Side Effects (in more detail)
• Meclofenamate Use in Pregnancy & Breastfeeding
• Drug Images
• Meclofenamate Drug Interactions
• Meclofenamate Support Group
• 0 Reviews for Meclofenamate - Add your own review/rating

• Meclofenamate Prescribing Information (FDA)


• meclofenamate Concise Consumer Information (Cerner Multum)


• Meclofenamate Sodium Monograph (AHFS DI)

Compare Meclofenamate with other medications

• Premenstrual Dysphoric Disorder
• Rheumatoid Arthritis

Microzide

Generic Name: hydrochlorothiazide (Oral route)

hye-droe-klor-oh-THYE-a-zide

Commonly used brand name(s)

In the U.S.

• Aquazide H


• Hydrocot


• Microzide


• Zide

Available Dosage Forms:

• Tablet


• Capsule


• Solution

Therapeutic Class: Cardiovascular Agent

Pharmacologic Class: Diuretic

Chemical Class: Thiazide

Uses For Microzide

Hydrochlorothiazide is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Hydrochlorothiazide is also used to treat fluid retention (edema) that is caused by congestive heart failure, severe liver disease (cirrhosis), kidney disease, or treatment with a steroid or hormone medicine.

Hydrochlorothiazide is a thiazide diuretic (water pill). It is used to help reduce the amount of water in the body by increasing the flow of urine. It may also be used for other conditions as determined by your doctor.

This medicine is available only with your doctor's prescription.

Before Using Microzide

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of hydrochlorothiazide capsules or tablets in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of hydrochlorothiazide capsules in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require an adjustment in the dose for patients receiving hydrochlorothiazide capsules.

No information is available on the relationship of age to the effects of hydrochlorothiazide tablets in geriatric patients. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require an adjustment in the dose for patients receiving hydrochlorothiazide tablets.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

Studies suggest that this medication may alter milk production or composition. If an alternative to this medication is not prescribed, you should monitor the infant for side effects and adequate milk intake.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Dofetilide

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acetyldigoxin


• Arsenic Trioxide


• Deslanoside


• Digitalis


• Digitoxin


• Digoxin


• Droperidol


• Flecainide


• Ketanserin


• Levomethadyl


• Lithium


• Metildigoxin


• Ouabain


• Proscillaridin


• Sotalol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alacepril


• Apazone


• Aspirin


• Benazepril


• Bepridil


• Bromfenac


• Captopril


• Carbamazepine


• Celecoxib


• Chlorpropamide


• Cholestyramine


• Cilazapril


• Cyclophosphamide


• Delapril


• Diclofenac


• Diflunisal


• Enalaprilat


• Enalapril Maleate


• Etodolac


• Fenoprofen


• Flurbiprofen


• Fosinopril


• Ginkgo


• Glipizide


• Gossypol


• Ibuprofen


• Ibuprofen Lysine


• Imidapril


• Indomethacin


• Ketoprofen


• Ketorolac


• Licorice


• Lisinopril


• Magnesium Salicylate


• Meclofenamate


• Mefenamic Acid


• Meloxicam


• Moexipril


• Nabumetone


• Naproxen


• Nepafenac


• Oxaprozin


• Pentopril


• Perindopril


• Piroxicam


• Quinapril


• Ramipril


• Salicylic Acid


• Salsalate


• Spirapril


• Sulindac


• Temocapril


• Tolmetin


• Topiramate


• Trandolapril


• Zofenopril

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Anuria (not able to urinate) or


• Sulfa drug allergy (e.g., sulfamethoxazole/trimethoprim, Bactrim®, Septra®)—Should not be used in patients with these conditions.

• Asthma or


• Diabetes or


• Electrolyte imbalance (e.g., hypercalcemia, hypokalemia, hyponatremia, hypomagnesemia) or


• Gout or


• Hypercholesterolemia (high cholesterol in the blood) or


• Hyperuricemia (high uric acid in the blood) or


• Hypoglycemia (low blood sugar) or


• Liver disease or


• Systemic lupus erythematosus (SLE)—Use with caution. May make these conditions worse.

• Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of hydrochlorothiazide

This section provides information on the proper use of a number of products that contain hydrochlorothiazide. It may not be specific to Microzide. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt) or potassium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to receive it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For fluid retention (edema):
  
  • For oral dosage form (tablets):
    
    • Adults—The usual dose is 25 to 100 milligrams (mg) daily as a single or divided dose. Your doctor may want you to take this dose every other day or on 3 to 5 days each week.
    
    
    • Children—Dose is based on body weight and must be determined by your doctor.
    
    
  
  


• For high blood pressure:
  
  • For oral dosage form (capsule):
    
    • Adults—At first, 12. 5 milligrams (mg) or one capsule once a day. Your doctor may want you to take this alone or together with other blood pressure medicines. Your doctor may increase your dose as needed. However, the dose is usually not more than 50 mg per day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For oral dosage form (tablets):
    
    • Adults—At first, 25 milligrams (mg) once a day. Your doctor may increase your dose as needed and may be taken as a single dose or divided into two doses.
    
    
    • Children—Dose is based on body weight and must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Microzide

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Check with your doctor right away if you have any of the following symptoms while taking this medicine: convulsions or seizures; decreased urine; drowsiness; dry mouth; excessive thirst; increased heart rate or pulse; muscle pains or cramps; nausea or vomiting; or unusual tiredness or weakness. These may be symptoms of a condition called hypokalemia or potassium loss.

Stop using this medicine and check with your doctor immediately if you have blurred vision, difficulty in reading, eye pain, or any other change in vision during or after treatment. This could be a sign of a serious eye problem. Your doctor will want you to have your eyes checked by an ophthalmologist (eye doctor).

This medicine may cause some people to become dizzy. Do not drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

Drinking alcoholic beverages may also make the dizziness worse. While you are taking this medicine, be careful to limit the amount of alcohol you drink.

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests (e.g., tests for parathyroid function) may be affected by this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes over-the-counter (nonprescription) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may tend to increase your blood pressure.

Microzide Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

• Abdominal or stomach pain


• back, leg, or stomach pains


• black, tarry stools


• bleeding gums


• blistering, peeling, or loosening of the skin


• bloating


• blood in the urine or stools


• bloody urine


• blue lips and fingernails


• blurred vision


• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


• chest pain


• chills


• clay-colored stools


• cloudy urine


• cold sweats


• confusion


• constipation


• cough or hoarseness


• coughing that sometimes produces a pink frothy sputum


• coughing up blood


• cracks in the skin


• darkened urine


• decrease in urine output or decrease in urine-concentrating ability


• decreased frequency or amount of urine


• diarrhea


• difficult, fast, or noisy breathing, sometimes with wheezing


• difficulty with breathing


• difficulty with swallowing


• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position


• dry mouth


• fast or irregular heartbeat


• fever


• flushed, dry skin


• fruit-like breath odor


• general body swelling


• general feeling of discomfort or illness


• general feeling of tiredness or weakness


• greatly decreased frequency of urination or amount of urine


• headache


• hives


• increased blood pressure


• increased hunger


• increased sweating


• increased thirst


• increased urination


• indigestion


• itching


• joint pain, stiffness, or swelling


• loss of appetite


• loss of heat from the body


• lower back or side pain


• muscle cramps or pain


• nausea or vomiting


• nosebleeds


• numbness, tingling, pain, or weakness in the hands or feet


• pain in the joints or muscles


• painful or difficult urination


• pains in the stomach, side, or abdomen, possibly radiating to the back


• pale skin


• pinpoint red spots on the skin


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• rash


• red, irritated eyes


• red skin lesions, often with a purple center


• red, swollen skin


• redness, soreness, or itching skin


• scaly skin


• seizures


• shortness of breath


• sore throat


• sores, ulcers, or white spots on the lips or in the mouth


• sores, welting, or blisters


• sugar in the urine


• swelling of the face, fingers, legs, ankles, feet, or lower legs


• swollen or painful glands


• tenderness of salivary glands


• thickening of bronchial secretions


• tightness in the chest


• trembling


• troubled breathing


• unpleasant breath odor


• unusual bleeding or bruising


• unusual tiredness or weakness


• unusual weight loss


• vomiting of blood


• weakness and heaviness of the legs


• weight gain


• wheezing


• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Cramping


• decreased interest in sexual intercourse


• difficulty having a bowel movement (stool)


• feeling of constant movement of self or surroundings


• hair loss or thinning of the hair


• inability to have or keep an erection


• increased sensitivity of the skin to sunlight


• loss in sexual ability, desire, drive, or performance


• muscle spasm


• pinpoint red or purple spots on the skin


• redness or other discoloration of the skin


• restlessness


• sensation of spinning


• severe sunburn


• weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Microzide side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Microzide resources

• Microzide Side Effects (in more detail)
• Microzide Use in Pregnancy & Breastfeeding
• Drug Images
• Microzide Drug Interactions
• Microzide Support Group
• 0 Reviews for Microzide - Add your own review/rating

• Microzide Prescribing Information (FDA)


• Microzide Concise Consumer Information (Cerner Multum)


• Microzide MedFacts Consumer Leaflet (Wolters Kluwer)


• Hydrochlorothiazide Prescribing Information (FDA)


• Hydrochlorothiazide Professional Patient Advice (Wolters Kluwer)


• Hydrochlorothiazide MedFacts Consumer Leaflet (Wolters Kluwer)


• Hydrochlorothiazide Monograph (AHFS DI)


• Esidrix Prescribing Information (FDA)

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Methadone

Pronunciation: METH-a-done
Generic Name: Methadone
Brand Name: Examples include Dolophine and Methadose

Methadone may cause severe and sometimes fatal heart and breathing problems. These problems may occur some time after you take a dose. Tell your doctor right away if you develop any new or worsening symptoms such as slowed or shallow breathing or irregular heartbeat. Your doctor will perform heart and lung function tests to check for side effects while you take Methadone. Keep all doctor and laboratory appointments. Talk with your doctor and be sure you understand the risks and benefits of using Methadone.

Do not take more than the recommended dose or take Methadone more often than prescribed. This can lead to overdose and possible death.

Methadone is used for:

Treating moderate to severe pain that is not relieved by other pain medicines. It is also used in treating narcotic addiction as part of a treatment program. It may also be used for other conditions as determined by your doctor.

Methadone is a narcotic analgesic. It works by acting on opiate pain receptors in the brain and on smooth muscle to provide pain relief.

Do NOT use Methadone if:

• you are allergic to any ingredient in Methadone


• you have slowed breathing or severe asthma, or if you are having an asthma attack


• you have a stomach or bowel blockage or certain severe bowel problems (eg, paralytic ileus)


• you have diarrhea caused by food poisoning or antibiotic use


• you are taking sodium oxybate (GHB)


• if you have taken a monamine oxidase inhibitor type B (MAOI-B) (eg, rasagiline, selegiline) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Methadone:

Some medical conditions may interact with Methadone. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have lung or breathing problems (eg, asthma), chronic obstructive pulmonary disease (COPD), sleep apnea, stomach or bowel problems (eg, bowel inflammation), stomach pain or constipation, liver or kidney problems, thyroid problems, or Addison disease


• if you have an abnormal curvature of the spine; narrowing of the urethra, trouble urinating, or an enlarged prostate ; low blood volume, blood pressure, or blood oxygen levels; low potassium or magnesium blood levels; increased pressure, tumors, or lesions in your head; a recent head injury; or seizures


• if you have a history of heart problems (eg, enlarged heart) or irregular heartbeat


• if you or a family member have a history of mental or mood problems (eg, anxiety, depression), suicidal thoughts or attempts, or alcohol or substance abuse


• if you are elderly, very ill, or very overweight, or if you have recently had stomach or intestine surgery

Some MEDICINES MAY INTERACT with Methadone. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Barbiturate anesthetics (eg, thiopental), benzodiazepines (eg, midazolam), cimetidine, MAOI-B (eg, rasagiline, selegiline), other narcotic analgesics (eg, morphine), phenothiazines (eg, promethazine), or sodium oxybate (GHB) because side effects such as sedation and slowed breathing may occur


• Antiarrhythmics (eg, amiodarone, dofetilide, flecainide, propafenone), antipsychotics (eg, haloperidol, paliperidone, ziprasidone), calcium channel blockers (eg, nifedipine), certain antiemetics (eg, dolasetron, droperidol), chloroquine, cisapride, diuretics (eg, furosemide), H₁ antagonists (eg, astemizole), kinase inhibitors (eg, lapatinib, nilotinib), lithium, macrolide antibiotics (eg, clarithromycin), phenothiazines (eg, chlorpromazine), quinolones (eg, ciprofloxacin), streptogramins (eg, quinupristin), tacrolimus, or tricyclic antidepressants (eg, desipramine) because the risk of QT prolongation may be increased


• Azole antifungals (eg, fluconazole, ketoconazole, voriconazole) or certain selective serotonin reuptake inhibitors (SSRIs) (eg, fluvoxamine, sertraline) because they may increase the risk of Methadone's side effects


• Abacavir, carbamazepine, efavirenz, HIV protease inhibitors (eg, amprenavir, lopinavir, nelfinavir, ritonavir), narcotic agonists/antagonists (eg, butorphanol, nalbuphine, pentazocine), narcotic antagonists (eg, naloxone, naltrexone), nevirapine, phenobarbital, phenytoin, rifampin, or St. John's wort because they may decrease Methadone's effectiveness


• Zidovudine because the risk of its side effects may be increased by Methadone


• Nucleoside reverse transcriptase inhibitors (NRTIs) (eg, abacavir, didanosine, stavudine) because their effectiveness may be decreased by Methadone

This may not be a complete list of all interactions that may occur. Ask your health care provider if Methadone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Methadone:

Use Methadone as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Methadone. Talk to your pharmacist if you have questions about this information.


• Take Methadone by mouth with or without food. Methadone is for oral use only and must not be injected.


• Methadone must be administered under close medical supervision.


• Take Methadone on a regular schedule to get the most benefit from it. It is more effective in preventing pain than in treating pain after it occurs.


• If Methadone is no longer needed, dispose of it as soon as possible. Ask your doctor or pharmacist how to dispose of Methadone properly.


• Always keep Methadone in a secure place to protect from theft.


• If you miss a dose of Methadone, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you miss your doses of Methadone for more than 2 days, contact your doctor before you start taking Methadone again.

Ask your health care provider any questions you may have about how to use Methadone.

Important safety information:

• Methadone may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Methadone with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Methadone; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Methadone may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.


• Breathing problems may occur some time after you take a dose of Methadone. Tell your doctor or seek medical care immediately if you notice trouble breathing (eg, slowed or shallow breathing) while you take Methadone


• Methadone may cause constipation. Constipation may be avoided by using a stool softener or fiber laxative.


• The risk of Methadone becoming habit-forming may be greater if you take it in high doses or for a long time. Do NOT take more than the recommended dose or use Methadone for longer than prescribed without talking with your doctor.


• Tell your doctor or dentist that you take Methadone before you receive any medical or dental care, emergency care, or surgery.


• Lab tests, including liver function, lung function, and heart function, may be performed while you use Methadone. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Methadone with caution in the ELDERLY; they may be more sensitive to its effects.


• Methadone should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Methadone may cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Methadone while you are pregnant. Methadone is found in breast milk. If you are or will be breast-feeding while you use Methadone, check with your doctor. Discuss any possible risks to your baby.

When used for long periods of time or at high doses, Methadone may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Methadone stops working well. Do not take more than prescribed.

Some people who use Methadone for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction.

If you suddenly stop taking Methadone, you may experience WITHDRAWAL symptoms including anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping.

Possible side effects of Methadone:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; dry mouth; headache; increased sweating; itching; lightheadedness; nausea; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; decreased sexual desire or ability; excessive drowsiness; fainting; fast, slow, or irregular heartbeat; hallucinations; loss of appetite; menstrual changes; mental or mood changes (eg, agitation, disorientation, exaggerated sense of well-being); seizures; severe or persistent dizziness or lightheadedness; shortness of breath; slow or shallow breathing; swelling of the arms, feet, or legs; trouble sleeping; trouble urinating; unusual bruising or bleeding.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Methadone side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include cold and clammy skin; coma; fainting; fast, slow, or irregular heartbeat; muscle weakness; pinpoint pupils; severe dizziness, drowsiness, or lightheadedness; slow, shallow, or difficult breathing.

Proper storage of Methadone:

Store Methadone between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Methadone out of the reach of children and away from pets.

General information:

• If you have any questions about Methadone, please talk with your doctor, pharmacist, or other health care provider.


• Methadone is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Methadone. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Methadone resources

• Methadone Side Effects (in more detail)
• Methadone Use in Pregnancy & Breastfeeding
• Drug Images
• Methadone Drug Interactions
• Methadone Support Group
• 217 Reviews for Methadone - Add your own review/rating

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Matzim LA

Generic Name: diltiazem (Oral route)

dil-TYE-a-zem

Commonly used brand name(s)

In the U.S.

• Cardizem


• Cardizem CD


• Cardizem LA


• Cartia XT


• Dilacor XR


• Dilt-CD


• Diltia XT


• Dilt-XR


• Diltzac


• Matzim LA


• Taztia XT


• Tiazac

Available Dosage Forms:

• Capsule, Extended Release


• Tablet, Extended Release


• Tablet


• Capsule, Extended Release, 24 HR


• Capsule, Extended Release, 12 HR

Therapeutic Class: Cardiovascular Agent

Pharmacologic Class: Calcium Channel Blocker

Chemical Class: Benzothiazepine

Uses For Matzim LA

Diltiazem is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .

Diltiazem is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, diltiazem relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload .

This medicine is available only with your doctor's prescription .

Before Using Matzim LA

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of diltiazem in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of diltiazem in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require an adjustment in the dose for patients receiving diltiazem .

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Cisapride

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acebutolol


• Alprenolol


• Amiodarone


• Aprepitant


• Atazanavir


• Atenolol


• Atorvastatin


• Betaxolol


• Bevantolol


• Bisoprolol


• Bucindolol


• Carteolol


• Carvedilol


• Celiprolol


• Clonidine


• Clozapine


• Colchicine


• Crizotinib


• Dantrolene


• Dilevalol


• Dronedarone


• Droperidol


• Erythromycin


• Esmolol


• Everolimus


• Fentanyl


• Labetalol


• Levobunolol


• Lurasidone


• Mepindolol


• Metipranolol


• Metoprolol


• Nadolol


• Nebivolol


• Oxprenolol


• Penbutolol


• Pindolol


• Propranolol


• Ranolazine


• Simvastatin


• Sotalol


• Talinolol


• Tertatolol


• Timolol


• Tolvaptan

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alfentanil


• Alfuzosin


• Amlodipine


• Aspirin


• Buspirone


• Carbamazepine


• Celecoxib


• Cilostazol


• Cimetidine


• Clopidogrel


• Colestipol


• Cyclosporine


• Dalfopristin


• Digitoxin


• Digoxin


• Dutasteride


• Efavirenz


• Enflurane


• Fosaprepitant


• Fosphenytoin


• Guggul


• Indinavir


• Lithium


• Lovastatin


• Methylprednisolone


• Midazolam


• Moricizine


• Nevirapine


• Nifedipine


• Phenytoin


• Quinupristin


• Rifampin


• Rifapentine


• Ritonavir


• Sirolimus


• St John's Wort


• Tacrolimus


• Triazolam

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Bowel blockage, severe or


• Congestive heart failure—Use with caution. May make this condition worse .

• Heart attack or


• Heart block (type of abnormal heart rhythm, can use if have a pacemaker that works properly) or


• Hypotension (low blood pressure), severe or


• Lung problem (e.g., pulmonary congestion) or


• Sick sinus syndrome (type of abnormal heart rhythm, can use if have a pacemaker that works properly)—Should not be used in patients with these conditions .

• Kidney disease or


• Liver disease—Use with caution. The effects of this medicine may be increased because of slower removal from the body .

Proper Use of diltiazem

This section provides information on the proper use of a number of products that contain diltiazem. It may not be specific to Matzim LA. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet .

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well .

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease .

Swallow the extended-release tablet or extended-release capsule whole. Do not open, crush, or chew it. It is best to take the extended-release capsule on an empty stomach .

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For chest pain:
  
  • For oral dosage form (tablets):
    
    • Adults—At first, 30 milligrams (mg) four times a day before meals and at bedtime. Your doctor may increase your dose if needed.
    
    
    • Children—Use and dose must be determined by your doctor .
    
    
  
  
  • For oral dosage form (extended-release tablets):
    
    • Adults—At first, 180 mg once a day either in the evening or in the morning. Your doctor may increase your dose if needed.
    
    
    • Children—Use and dose must be determined by your doctor .
    
    
  
  
  • For oral dosage form (extended-release capsules):
    
    • Adults—At first, 120 mg once a day in the morning. Your doctor may increase your dose if needed.
    
    
    • Children—Use and dose must be determined by your doctor .
    
    
  
  

• For high blood pressure:
  
  • For oral dosage form (extended-release tablets):
    
    • Adults—At first, 180 to 240 milligrams (mg) once a day either in the morning or at bedtime. Your doctor may increase your dose if needed.
    
    
    • Children—Use and dose must be determined by your doctor .
    
    
  
  
  • For oral dosage form (extended-release capsules):
    
    • Adults—At first, 180 to 240 mg once a day in the morning. Your doctor may increase your dose if needed.
    
    
    • Children—Use and dose must be determined by your doctor .
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Matzim LA

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects .

Low blood pressure (hypotension) may occur while taking this medicine. Check with your doctor right away if you have the following symptoms: blurred vision; confusion; severe dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly; sweating; or unusual tiredness or weakness .

Check with your doctor right away if you have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem .

Serious skin reactions can occur with this medicine. Check with your doctor right away if you have any of the following symptoms while taking this medicine: blistering, peeling, or loosening of the skin; chills; cough; diarrhea; itching; joint or muscle pain; red skin lesions, often with a purple center; skin rash; sore throat; sores, ulcers, or white spots in the mouth or on the lips; or unusual tiredness or weakness .

Matzim LA Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Body aches or pain


• congestion


• cough


• dryness or soreness of throat


• fever


• hoarseness


• runny nose


• tender or swollen glands in neck


• trouble in swallowing


• voice changes

Less common

• Chest pain or discomfort


• chills


• diarrhea


• difficult or labored breathing


• feeling faint, dizzy, or lightheaded


• feeling of warmth or heat


• flushing or redness of skin, especially on face and neck


• general feeling of discomfort or illness


• headache


• joint pain


• loss of appetite


• muscle aches and pains


• nausea


• shivering


• shortness of breath


• slow or irregular heartbeat


• sore throat


• sweating


• swelling of hands, ankles, feet, or lower legs


• tightness in chest


• trouble sleeping


• unusual tiredness or weakness


• vomiting


• wheezing

Incidence not known

• Blistering, peeling, or loosening of skin


• itching


• large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


• no heart beat


• red irritated eyes


• red skin lesions, often with a purple center


• sores, ulcers, or white spots in mouth or on lips

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Sneezing


• stuffy nose

Less common

• Acid or sour stomach


• belching


• constipation


• continuing ringing or buzzing or other unexplained noise in ears


• degenerative disease of the joint


• difficulty in moving


• hearing loss


• heartburn


• indigestion


• lack or loss of strength


• muscle aching or cramping


• muscle pains or stiffness


• pain or tenderness around eyes and cheekbones


• rash


• sleeplessness


• stomach discomfort, upset, or pain


• swollen joints


• unable to sleep

Incidence not known

• Hair loss or thinning of hair

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Matzim LA side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Matzim LA resources

• Matzim LA Side Effects (in more detail)
• Matzim LA Use in Pregnancy & Breastfeeding
• Drug Images
• Matzim LA Drug Interactions
• 0 Reviews for Matzim LA - Add your own review/rating

• Matzim LA Prescribing Information (FDA)


• Diltiazem Prescribing Information (FDA)


• Cardizem Consumer Overview


• Cardizem MedFacts Consumer Leaflet (Wolters Kluwer)


• Cardizem Prescribing Information (FDA)


• Cardizem CD Prescribing Information (FDA)


• Cardizem CD 24-Hour Sustained-Release Beads Capsules MedFacts Consumer Leaflet (Wolters Kluwer)


• Cardizem LA Prescribing Information (FDA)


• Cardizem LA 24-Hour Extended-Release Beads Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Cartia XT Prescribing Information (FDA)


• DILT-CD Prescribing Information (FDA)


• Dilacor XR Prescribing Information (FDA)


• Dilacor XR 24-Hour Sustained-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)


• Dilt-XR Prescribing Information (FDA)


• Diltia XT Prescribing Information (FDA)


• Diltiazem Hydrochloride Monograph (AHFS DI)


• Taztia XT Prescribing Information (FDA)


• Taztia XT 24-Hour Extended-Release Beads Capsules MedFacts Consumer Leaflet (Wolters Kluwer)


• Tiazac Prescribing Information (FDA)


• Tiazac Consumer Overview

Compare Matzim LA with other medications

• Angina Pectoris Prophylaxis
• Atrial Fibrillation
• Atrial Flutter
• Heart Failure
• High Blood Pressure
• Raynaud's Syndrome
• Supraventricular Tachycardia

mannitol

Generic Name: mannitol (MAN it ol)

Brand names: Osmitrol, Resectisol, Aridol

What is mannitol?

Mannitol is a diuretic.

Mannitol is used to force urine production in people with acute (sudden) kidney failure. Increased urine production helps prevent the kidneys from shutting down, and also speeds up elimination of certain toxic substances in the body.

Mannitol is also used to reduce swelling and pressure inside the eye or around the brain.

Mannitol may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about mannitol?

You should not be treated with this medication if you are allergic to mannitol, or if you have severe or long-term kidney disease, lung swelling or congestion, severe dehydration, bleeding in your brain not caused by surgery, or if your kidneys have already shut down and you are unable to urinate. To be sure mannitol is helping your condition and not causing harmful effects, your blood will need to be tested often. This will help your doctor determine how long to treat you with mannitol. Your heart function will also need to be tested.

What should I discuss with my health care provider before receiving mannitol?

You should not be treated with this medication if you are allergic to mannitol, or have certain conditions. Be sure your doctor knows if you have:

• 
  

  severe or long-term kidney disease;

  
  


• 
  

  swelling or congestion in your lung;

  
  


• 
  

  bleeding in your brain that is not related to surgery;

  
  


• 
  

  severe dehydration; or

  
  


• 
  

  if your kidneys have already shut down and you are unable to urinate.

  
  

FDA pregnancy category C. This medication may be harmful to an unborn baby. Before receiving mannitol, tell your doctor if you are pregnant. It is not known whether mannitol passes into breast milk or if it could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.

How is mannitol given?

Mannitol is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. The medicine must be given slowly through an IV infusion, and you may receive the medication around the clock.

To be sure mannitol is helping your condition and not causing harmful effects, your blood will need to be tested often. This will help your doctor determine how long to treat you with mannitol. Your heart function will also need to be tested.

What happens if I miss a dose?

Since mannitol is given as needed by a healthcare professional, it is not likely that you will miss a dose.

What happens if I overdose?

Seek emergency medical attention if you think you have received too much of this medicine.

Since mannitol is given by a healthcare professional, it is not likely that you will receive an overdose.

What should I avoid while receiving mannitol?

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are being treated with mannitol.

Mannitol side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tell your caregivers at once if you have any of the following symptoms. Some of these may be caused by your kidney condition and are not side effects of mannitol:

• 
  

  dry mouth, increased thirst, blurred vision, or seizure (convulsions);

  
  


• 
  

  swelling, pain, or skin changes where the medicine was injected;

  
  


• 
  

  chest pain, fast heart rate;

  
  


• 
  

  feeling like you might pass out;

  
  


• 
  

  feeling short of breath, even with mild exertion;

  
  


• 
  

  swelling, rapid weight gain; or

  
  


• 
  

  if you stop urinating.

  
  

Less serious side effects may include:

• 
  

  nausea, vomiting;

  
  


• 
  

  runny nose;

  
  


• 
  

  dizziness;

  
  


• 
  

  chills; or

  
  


• 
  

  mild skin rash.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Mannitol Dosing Information

Usual Adult Dose for Oliguria:

Renal function test dose prior to initiation of treatment: 0.2 g/kg IV over 3 to 5 min resulting in a urine flow of at least 30 to 50 mL/hr. A second test dose may be administered if the urine flow does not increase. If no response is seen following the second test dose, the patient should be reevaluated.

Treatment: 300 to 400 mg/kg (21 to 28 g for a 70 kg patient) or up to 100 g of 15% to 20% solution IV once. Treatment should not be repeated in patients with persistent oliguria.

Prevention (for use during cardiovascular and other types of surgery): 50 to 100 g IV. usually a 5 , 10, or 20% solution is used depending on the fluid requirements of the patient.

Usual Adult Dose for Cerebral Edema:

0.25 to 2 g/kg as a 15 to 20% solution IV over at least 30 min administered not more frequently than every 6 to 8 hrs.

To yield a satisfactory reduction in intracranial pressure, the osmotic gradient between the blood and cerebrospinal fluid should remain approximately 20 mOsmol.

In small &/or debilitated patients 500 mg/kg may be sufficient.

What other drugs will affect mannitol?

There may be other drugs that can interact with mannitol. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More mannitol resources

• Mannitol Dosage
• Mannitol Use in Pregnancy & Breastfeeding
• Mannitol Drug Interactions
• Mannitol Support Group
• 0 Reviews for Mannitol - Add your own review/rating

• mannitol Inhalation Advanced Consumer (Micromedex) - Includes Dosage Information


• Mannitol MedFacts Consumer Leaflet (Wolters Kluwer)


• Mannitol Monograph (AHFS DI)


• Aridol Consumer Overview


• Osmitrol Prescribing Information (FDA)

Compare mannitol with other medications

• Cerebral Edema
• Diagnosis and Investigation
• Oliguria

Where can I get more information?

• Your doctor or pharmacist can provide more information about mannitol.

Metamucil Smooth Texture Powder

Pronunciation: SILL-i-um
Generic Name: Psyllium
Brand Name: Examples include Konsyl and Metamucil Smooth Texture

Metamucil Smooth Texture Powder is used for:

Treating occasional constipation and restoring regularity. It may also be used for other conditions as determined by your doctor.

Metamucil Smooth Texture Powder is a fiber laxative. It works by absorbing water and swelling in the intestines. This helps the stool form the bulk necessary to be easily passed.

Do NOT use Metamucil Smooth Texture Powder if:

• you are allergic to any ingredient in Metamucil Smooth Texture Powder


• you have appendicitis, difficulty swallowing, severe constipation, intestinal blockage, or undiagnosed rectal bleeding

Contact your doctor or health care provider right away if any of these apply to you.

Before using Metamucil Smooth Texture Powder:

Some medical conditions may interact with Metamucil Smooth Texture Powder. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a sudden change in bowel habits persisting for more than 2 weeks


• if you have stomach or intestinal pain, nausea, or vomiting

Some MEDICINES MAY INTERACT with Metamucil Smooth Texture Powder. However, no specific interactions with Metamucil Smooth Texture Powder are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Metamucil Smooth Texture Powder may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Metamucil Smooth Texture Powder:

Use Metamucil Smooth Texture Powder as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Metamucil Smooth Texture Powder may be taken with or without food.


• Empty the contents of 1 packet (unless directed by your doctor to use a different dose) into an empty glass. Mix Metamucil Smooth Texture Powder with a full glass (at least 8 oz or 240 mL) of water or other liquid. Stir briskly and drink immediately. If the mixture thickens, add more liquid and stir.


• Do not take other oral medicines within 2 hours before or 2 hours after taking Metamucil Smooth Texture Powder.


• If you miss a dose of Metamucil Smooth Texture Powder, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Metamucil Smooth Texture Powder.

Important safety information:

• If your symptoms do not improve within 7 days or if they become worse, check with your doctor.


• Do not take additional laxatives or stool softeners with Metamucil Smooth Texture Powder unless directed by your doctor.


• Do not use Metamucil Smooth Texture Powder if you experience stomach pain, nausea, vomiting, or rectal bleeding, except under the direction of your doctor.


• If you notice a sudden change in bowel habits that lasts for 2 weeks or more, do not continue using Metamucil Smooth Texture Powder. Instead, check with your doctor.


• Taking this product without enough liquid may cause it to swell and block your throat or esophagus and may cause choking. Do not take this product if you have difficulty swallowing. If you experience chest pain, vomiting, or difficulty swallowing or breathing after taking this product, seek immediate medical attention.


• Do not use Metamucil Smooth Texture Powder in CHILDREN younger than 12 years of age without first checking with your doctor.


• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Metamucil Smooth Texture Powder, discuss with your doctor the benefits and risks of using Metamucil Smooth Texture Powder during pregnancy. It is unknown if Metamucil Smooth Texture Powder is excreted in breast milk. If you are or will be breast-feeding while you are using Metamucil Smooth Texture Powder, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Metamucil Smooth Texture Powder:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abdominal fullness; minor bloating.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; difficulty swallowing; trouble breathing; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Metamucil Smooth Texture side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Metamucil Smooth Texture Powder:

Store Metamucil Smooth Texture Powder at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Metamucil Smooth Texture Powder out of the reach of children and away from pets.

General information:

• If you have any questions about Metamucil Smooth Texture Powder, please talk with your doctor, pharmacist, or other health care provider.


• Metamucil Smooth Texture Powder is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Metamucil Smooth Texture Powder. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Metamucil Smooth Texture resources

• Metamucil Smooth Texture Side Effects (in more detail)
• Metamucil Smooth Texture Use in Pregnancy & Breastfeeding
• Metamucil Smooth Texture Drug Interactions
• Metamucil Smooth Texture Support Group
• 0 Reviews for Metamucil Smooth Texture - Add your own review/rating

Compare Metamucil Smooth Texture with other medications

• Constipation
• Dietary Fiber Supplementation
• Irritable Bowel Syndrome